Nineteenth century physics and chemistry – in particular, spectroscopy - gave birth to not only classical electromagnetic theory but also laid the groundwork for the development of quantum mechanics. The richness of the spectra from both earth-based and astronomical sources was at the same time beautiful and bedeviling. It took tremendous care and thought to make sense of these spectra. Wave resonances and complex structures were part of many models of “atoms”, long before the electron was discovered and the development of the Schrodinger equation. Today, we need spectroscopy to design schemes for single quantum state control over ever more complex quantum systems. A milestone result is that we can now hold single polyatomic molecules in optical tweezers and have single quantum state control and optical cooling of symmetric and asymmetric top molecules. Furthermore, entanglement and iSWAP quantum gates between single molecules is now a reality. I will discuss features of polyatomic molecules that can be used in quantum simulation/computation and the search for physics beyond the Standard Model. I will discuss our results on the laser cooling of polyatomic molecules into the ultracold regime, including the laser cooling of several different polyatomic species. We realize a tweezer array of single CaOH molecules, a robust MOT and optical dipole trap for SrOH, and one-dimensional laser cooling of CaOCH 3 . In very recent work we have characterized a new qubit, one composed of parity doublet states in a vibrational bending mode of CaOH. This sets the stage for using SrOH and RaOH for future experiments searching for the electron electric dipole moment, a probe for T-violating BSM physics up to the 1000 TeV range, as well as a state-of-the-art probe for ultralight Dark Matter.